11/29/2022 0 Comments Iron wars 2018![]() ![]() The overall structure includes a unique cationic region on its N-terminal (See figure 3). In addition to its antibacterial defenses, lactoferrin performs other functions in the body. All transferrin proteins bind with high affinity to iron (III) ions, but lactoferrin has the highest binding affinity (K D ~ 10 -20 M compared with K D ~ 10 -9 M for transferrin). 4 The ability for lactoferrin to retain iron in a pH far below the biological level of 7.4 makes lactoferrin a more effective tool in the war over iron than transferrin, but less effective as an iron source for the body itself.įigure 2: Comparison of the structures of three iron chelating proteins in the transferrin family: Lactoferrin, transferrin, and ovotransferrin. 4 A pH of this acidity can be found in the body in places such as inflammation sites, cellular vesicles, or the stomach. 3 On the other hand, lactoferrin binds to iron with a much higher affinity, and the ion is not known to be released until pH drops to around 2-3. Transferrin has a lower binding affinity to iron than lactoferrin does, and a slight dip below biological pH can trigger the protein to release its ion. 2 Transferrin, while in some cases able to prevent bacterial infection, is used more efficiently as an iron transport protein. 2 Lactoferrin is a member of the transferrin family, a group of proteins that bind specifically to iron and perform various functions in the body (see figure 2). Left: human protein, lactoferrin.Įnter to the scene lactoferrin, a iron-chelating protein that has an extremely high binding affinity for iron (III). Faecalis siderophore, ferric hydroxamate. 1 As a result of this mutual need, iron wars break out between bacteria and the human body, and each side has used scientific methods to more efficiently acquire this resource.įigure 1: Cartoon depicting the “iron wars” between human and bacterial iron-sequestering proteins. 1 However, humans aren’t the only organisms that need this ion as a nutrient source bacterial species depend on ions like iron to survive. While largely known for its rusting abilities, iron is also the catalyst for numerous metabolic processes, a binding agent in molecules like hemoglobin, and is even speculated to be a contributing ion to the early formation of macromolecules that eventually led to life forms. Wars can be started over metals like gold or silver, but the human body wages an internal war against pathogens on a daily basis over a seemingly insignificant metal: iron (see figure 1). Feige first announced plans for Armor Wars in late 2020.\) Little is known about the logline for Armor Wars although it was brought up earlier this month at Disney’s D23 Expo when Cheadle joined Marvel Studios producer and president Kevin Feige on stage, revealing a logo for what was then touted as being a six-episode event series. No directors had been officially attached and it is unclear when an Armor Wars feature would pop on Marvel’s timeline of its phases of movies and Disney series. Marvel had been eyeing a 2023 start of production on the series, but the few people who were gearing up for that were notified Thursday of the change of direction. Yassir Lester, who was acting as head writer on the series, will remain as its feature scribe. ![]() Like all Marvel movies, it is intended for a theatrical release.ĭon Cheadle, who is reprising his longtime Marvel Cinematic Universe role as Colonel James “Rhodey” Rhodes, AKA War Machine, remains on board to star. ![]() Sources say the studio was committed in getting the story told the right way and in that process realized that a feature was better suited for the project. ![]()
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